Tricyclic Antidepressants (TCAs)

TCAs tend to be given for moderate to severe depression when a doctor cannot pinpoint a specific cause for depression, and where symptoms such as loss of appetite and sleepy disturbances are present. Examples of Tricyclic Antidepressants (TCAs) and related Antidepressants are -

amitriptyline hydrochloride
clomipramine
dosulepin
doxepin
maprotiline
mianserin
trazodone
trimipramine
amoxapine
imipramine
lofepramine
nortriptyline

How Tricyclic Antidepressants (TCAs) works ?

Tricyclic drugs (TCAs) (they are called tricyclic because of their chemical structure, which comprises 3 chains) work by preventing reuptake of norepinephrine or serotonin by the forst neuron's terminal. The rationale is that if depression is linked to low levels of one of the neurotransmitters in the brain, then preventing reuptake means more of the neurotransmitter will remain in the synapse to ensure it stimulates the second, so on.

Side effects of taking Tricyclic Antidepressants (TCAs)

Important Facts and information on Tricyclic Antidepressants (TCAs)

How Tricyclic Antidepressants (TCAs) works

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